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Another metabolic pathway involves the enzyme, glutamine synthetase, present in several tissues, which converts ammonia with glutamate into glutamine, achieving its renal secretion through the synthesis of urea from glutamine

Neither medication significantly affects the metabolism of the other through cytochrome P450 enzyme systems, meaning they are unlikely to alter each other's blood levels or efficacy

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Labels include precautions for rare events such as pancreatitis and animal findings that prompted attention to thyroid C-cell tumors