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Cellular assays have enabled detailed examination of second messenger dynamics, such as cyclic AMP generation and calcium mobilization, while animal models have provided insight into systemic signal coordination and feedback regulation along the hypothalamic pituitary axis
Sun, Y., Wang, X
As a result, the balance between cell proliferation and apoptosis is disrupted, contributing to gastric carcinogenesis ( waf1/cip1 , proapoptotic protein Bax-1 and cleaved caspase 3 but also reversed the increase in the cell proliferation markers including cyclin D1 and PCNA, suggesting that lycopene protects the gastric mucosa from smoking-induced damage through p53-dependent cell cycle control and apoptosis, and may counteract the development of gastric cancer associated with smoking (Figure 3)
Lord RS, Bralley JA
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