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Why is Semax studied in nasal spray format

Recent investigations into the gut microbiome reveal a concerning prevalence of dysbiosis in ME/CFS patients, characterized by reduced microbial diversity and an imbalance between beneficial and harmful bacteria [1, 10,11,12,13,14]

A disrupted NAD + /NADH balance may contribute to the development of many diseases, including cardiovascular and neurodegenerative disorders such as Alzheimer's and Parkinson's disease, metabolic disorders such as type 2 diabetes, and inflammatory skin conditions such as acne and psoriasis (135137)

This includes regulations concerning research chemicals, controlled substances, and pharmaceuticals within the researchers jurisdiction

But the mechanism here is plausible enough to warrant attention in human studies too