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In contrast, a study in which 12 patients with IEI and 17 healthy controls underwent cerebral F-18 fluorodeoxyglucose (F-18 FDG) positron emission tomography (PET) found no consistent pathological cognitive performance and functional imaging pattern in MCS patients [59]

Importantly, their glucose-dependent mechanism means insulin secretion only occurs when blood glucose levels are elevated, substantially reducing hypoglycaemia risk