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In the Phase 2 obesity trial (Jastreboff et al., New England Journal of Medicine , 2023), investigators reported dose-dependent mean weight reduction of up to 17.5% at 24 weeks and up to 24.2% at 48 weeks

Meldonium activates the PPAR/PGC1 pathway and decreases ROS production in mitochondria and the risk of MD, which in turn may contribute to a reduction in cardiac injury [34]