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This discovery led to the approval of Wegovy, a higher-dose version of semaglutide specifically designed for weight management

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Semaglutide is intentionally started at a low dose and gradually increased over several weeks to months, allowing the gastrointestinal system time to adapt

When Ozempic received FDA approval in December 2017, its labeling mentioned only mild gastrointestinal side effects like nausea and vomiting common and generally temporary reactions to GLP-1 medications

Krempf M, Louvet JP, Allanic H, Miloradovich T, Joubert JM, Attali JR