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When injected with anti-cancer drugs directly into the tumor, scientists saw "markedly suppressed liver tumor growth as well as prolonged survival time with little toxicity." A group of phytonutrients called saponins are found in high qualities in asparagus

10.1111/liv.15262 48 LiaoW.WenY.WangJ.ZhaoM.LvS.ChenN.et al (2023)

We hypothesize that (i) the slow inhibition observed in the biochemical assay with the recombinant protein with some of the compounds is due to their preferential binding to a slowly populated conformer of the NADP + -TGR(H) complex and (ii) this conformer is already populated in the worm cell interior accounting for the more rapid inhibition of TGR observed in ex vivo worms with the slow inhibitors

The molecular identification of these channels has been subject to intense research

Geoffroy PA, Micoulaud Franchi JA, Lopez R, Poirot I, Brion A, Royant-Parola S, Etain B (2017) Comment caractriser et traiter les plaintes de sommeil dans les troubles bipolaires