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Research models show it modulates central signaling pathways associated with pigmentation, appetite regulation, and autonomic response distinct from peripherally-acting peptides

Chen D, Chu B, Yang X et al (2021a) iPLA2-mediated lipid detoxification controls p53-driven ferroptosis independent of GPX4

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Artificially providing GLP-1 levels several times higher than normal over a long period may cause you to produce less of your own natural GLP-1, and may also make you less sensitive to its effects, he said in a statement shared with CNN by the Science Media Centre