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These nanocarriers can discharge their content in accordance with some intracellular or extracellular signals such as pH or temperature, enzymes or an external magnetic field [329, 330]

A major challenge for laboratories studying enzyme inhibition and metabolic signaling is distinguishing true target engagement from effects created by inconsistent preparation and measurement design

Empirical work suggests a neurocognitive mechanism underpins motivational differences: the integration of costs and benefits during decision-making (effort-based decision-making) [3, 4]

10.1073/pnas.91.22.10625 Proc

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