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This leads to more LDL cholesterol being removed from your bloodstream ( Diabetes, high blood sugar levels, and obesity are also major risk factors for heart disease, and this supplement seems to help improve all of these conditions ( Given the beneficial effects on all these risk factors, it seems likely that berberine could reduce the risk of heart disease, though more research is needed
Readers can review the FDA's March 2026 announcement directly at FDA.gov
Interestingly, astrocytes often do not transition into this more damaging/senescent-like state unless microglia induce the switch through the release of cytokines like IL-1 and TNF (Herx et al., 2000