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The primary function of GR is to catalyze the reduction of oxidized glutathione (GSSG) to its reduced form (GSH) using NADPH as an electron donor

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In addition, a case-control study reported that the A allele was more prevalent in individuals affected by Hashimoto thyroiditis (HT) a T-cell-mediated autoimmune disease resulting in the destruction of thyroid cells than in healthy controls (37)

Reduced activity of Arabidopsis thaliana HMT2, a methionine biosynthetic enzyme, increases seed methionine content