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Limitations in an RCT can outweigh the benefits, for example excessive dosages, excessive treatment delays, or remote survey bias may have a greater effect on results

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Most patients begin with a 0.25 mg dose in week one, then progress through 0.5 mg, 1.0 mg, 1.7 mg, and up to 2.4 mg maintenance depending on tolerability and clinical response

By contrast, both plasma and urine TMAO levels were significantly increased after carnitine supplementation (Figure S1a right panel)