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Este fenmeno es lo que se denomina early worsening, que se aplica a otros tratamientos en los que hay un descenso muy marcado de la glucemia (28)

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Researchers should design protocols with matched dosing equivalents and clearly defined primary endpoints, as the compounds differ in receptor pharmacology and potency

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It mimics the GLP*1 hormone that is released in the gastrointestinal tract in response to eating