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Because GLP-1 medications reduce appetite, it can be easy to under-eat protein, which may lead to muscle loss
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Interestingly, another mechanism was proposed as an alternative way to stabilize NRF2 through the interaction between the autophagy adaptor protein p62/sequestosome-1 (p62/SQSTM1) and KEAP1, which leads to the sequestration of KEAP1 in the autophagy-deficient cells and enables NRF2 accumulation [20]
Liraglutide improved the cardiac endoplasmic reticulum stress response and also improved cardiac function by an AMP-activated protein kinase-dependent mechanism [82]