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It may be a weaker fit if you have a complex medical history that you'd rather discuss with a provider in person before starting a GLP-1, if you already have insurance coverage that makes a branded FDA-approved option cost-competitive, or if the idea of asynchronous, text-based care (rather than a live conversation with a provider) doesn't sit well with you for a prescription medication decision

In this context, robust headtohead clinical evidence becomes critical when evaluating newer formulations against established reference products

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Metformin works by reducing insulin resistance and lowering blood sugar, but its weight-loss effect is more modest