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If the provision of some of these vitamins is insufficient, then a compensatory shift in pathways within OCM may occur (Reference Fernndez-Roig, Cavall-Busquets and Fernandez-Ballart12) but also it might have a negative impact on SAM synthesis with impairment of transmethylation reactions (Reference Bottiglieri11)

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Effect of nanoparticle composition, size, shape, and stiffness on penetration across the bloodbrain barrier

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