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Bach AC, Babayan VK

Those medications work through fewer receptor pathways and have lower maximum efficacy in clinical trials

Philippou, A., Halapas, A., Maridaki, M., & Koutsilieris, M

This is particularly true for patients who were started on insulin early in their disease course when their beta cells still had significant function, gained weight on insulin therapy, have A1C levels that might respond to GLP-1-mediated insulin secretion, or want the cardiovascular and weight loss benefits that GLP-1 medications offer

Ageing Res Rev 26:8195 Li J, Ichikawa T, Villacorta L, Janicki JS, Brower GL, Yamamoto M, Cui T (2009) Nrf2 protects against maladaptive cardiac responses to hemodynamic stress