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Based on Phase 2 trial data, the most common side effects are gastrointestinal, including nausea, vomiting, diarrhoea, and constipation, which are most pronounced during dose escalation

Although the serotonergic pathway may create a physiological decrease in sexual desire for patients taking GLP-1 agonists, we postulate that this diminishing influence of GLP-1 agonism is both compounded by factors such as undesirable side effects and increased SHBG and offset by the enhancing influences on sexual desire such as increased total testosterone, and improved vascular reactivity and mood

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Exposure can be acute or chronic (low-level, long-term), leading to a range of health effects