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En humanos, los ensayos clnicos de fase II en obesidad evaluaron distintas dosis: si bien se observaron seales de reduccin de peso y un buen perfil de tolerancia, los estudios no alcanzaron de forma robusta los criterios de valoracin primarios de eficacia, lo que detuvo su desarrollo como frmaco anti-obesidad

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The cardioprotective effect of metformin in patients with type 2 diabetes is not only attributable to its glucose-lowering effects but also to its significant antihypertensive properties [33]

Sirtuin 3-dependent mitochondrial redox homeostasis protects against ages-induced intervertebral disc degeneration

pylori can be effectively treated with antibiotics