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Mar Drugs 12(5):588601 Lipinski CA, Lombardo F, Dominy BW, Feeney PJ (2001) Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings

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tarda to kanamycin by a mechanism involving activation of the pyruvate cycle (the P cycle), increased NADH production and PMF, and increased drug uptake 10,55

(c) Hepatic encephalopathy [88]

ALS-associated SOD1 mutants produce free radicals (ONOO or OH ) and some mutants lose its catalytic activity, which in turn produces highly unstable intermediate products and tyrosine (Abe et al., 2006)