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"The effects of topical glutathione-containing formulations on eczema symptoms: A randomized controlled trial." Journal of Clinical and Aesthetic Dermatology, 13(6), 22-28

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It acts as a physiological ligand for Fe 2 + , promoting assembly of iron-sulfur (Fe-S) clusters and biosynthesis of Fe-S proteins, which participate in essential biological functions including electron transfer, the Krebs cycle, maintenance of genome integrity, enzymatic catalysis, and iron homeostasis 15

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These unique features plus PD-L1 expression on the exosome surface, contribute to defective immune effector cell function at both local and systemic levels (106108)