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Normally, if you diet, your body fights back by increasing appetite and reducing energy burn, a survival mechanism that can make weight loss frustrating

[2] NSAIDs carry a small increased risk of cardiovascular events with prolonged use

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Seek immediate medical attention if you develop a lump in your neck, unexplained hoarseness, difficulty swallowing, or persistent shortness of breath these can be signs of thyroid abnormalities

These factors underline the need for careful patient selection, structured behavioral support, and real-world studies to assess persistence and tolerability in psychiatric contexts