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For instance, they encapsulated sonosensitizer protoporphyrin (PpIX) in disulfide bond-bridged hollow MONs for sonodynamic therapy (SDT)

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Either way, the treatment is quick, requires no downtime, and results typically last 912 months or more

The likelihood of pre-existing resistant clones is shaped by tumor size, baseline mutational burden, fitness costs, and microenvironmental constraints, making therapeutic failure an expected evolutionary outcome under strong selective pressure