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[11] SIBO is often associated with an increased intestinal permeability and this, combined with hypochlorhydria, can exacerbate gut inflammation, leading to compromised enterocyte function, low digestive enzyme production and, because the luminal content is able to interact with immune cells, will fuel systemic inflammation

Ipamorelin is a GH secretagogue pentapeptide that selectively activates the GHS-R1a receptor (ghrelin receptor) without significantly stimulating the release of cortisol, prolactin, or ACTH

The percentage of subjects with one deficit increased from 18 subjects (69.2%) to 19 subjects (73.1%) after 10 weeks, while the percentage of subjects with two deficits decreased from ten subjects (30.8%) to four subjects (15.4%) after 10 weeks intervention