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Compared to curcumin itself, the biological effectiveness of curcumin metabolites, excluding 4HC, is considerably reduced (82, 116)

The production of ROS, produced by the inflammatory immune cells recruited to the location of inflammation, contributes to DNA damage, which could also lead to the arrest of the mismatch repair system [236]

Escalation speed matters as much as final dose

Zhonghua Shao Shang Za Zhi 36(5):378387 Kumar S et al (2015) A novel quinoline based second-generation mTOR inhibitor that induces apoptosis and disrupts PI3K-Akt-mTOR signaling in human leukemia HL-60 cells

Articles not related to skeletal muscle or mitochondrial biology, lacking relevance to rotator cuff injury or muscle atrophy, or consisting solely of commentaries or conference abstracts were excluded