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41 Further, MSH induces expression of the immunosuppressive cytokine IL10 and exhibits further immunomodulatory effects through suppressing the expression of intercellular adhesion molecules and cell surface molecules including intercellular adhesion molecule 1, CD40, CD86 and ectopic major histocompatibility complex class I

in silico docking studies with allicin revealed the formation of S -thioallylations at Cys145, Cys85 and Cys156 of M pro and of Cys622 of RdRp, indicating the potential of allicin to attenuate SARS-CoV-2 replication (Shekh et al., 2020)

Immediately discontinue 5-amino-1MQ and return to tirzepatide monotherapy until symptoms resolve

Patients with pre-existing gastrointestinal conditionsinflammatory bowel disease, irritable bowel syndrome, or previous bowel surgeryshould maintain closer monitoring and lower thresholds for seeking medical input, as these populations may experience more pronounced or complex digestive effects