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most comprehensive single molecule Tirzepatide, the dual agonist, produced about 20.9% weight loss at its top dose in SURMOUNT-1 ( Jastreboff et al., NEJM 2022 ) and strong glycemic control in the SURPASS program ( Fras et al., NEJM 2021 )

J Cell Sci 135 , jcs259073 (2022)

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For example, Icariin I (GH01) (143), extracted from the herb Epimedium , has been reported to significantly restore the intestinal barrier function, remodel the microbial composition, and regulate the host immune status in OVX mice, thereby effectively improving osteoporosis and bone loss, and has undergone a preliminary exploration in the innovative application of TCM