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Nature (2016) 539(7629):3905

If your GIP receptors have desensitized alongside your GLP-1 receptors, switching to a pure GLP-1 agonist removes the GIP stimulus entirely, allowing those receptors to recover while you maintain GLP-1 mediated appetite suppression with a different agonist profile

Wilson's disease autosomal recessive copper-transport defect causing copper accumulation is the condition most often cited in community sources as a contraindication

GLP-1 activation decreases appetite through multiple pathways

However, as acral lentiginous melanoma is rare, only a small number of patients have been included in clinical trials