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The best option depends on several factors, including health history, metabolic health, medication tolerance, side effect response, and long-term weight loss goals

PubMed Systematic reviewGLP-1 class evidence2025 Effect of glucagon-like peptide-1 receptor agonists and co-agonists on body composition Supports body-composition, lean-mass, and metabolic-risk context

However, the appetite-suppressing effects of Ozempic may take a few days to become noticeable, and the degree of change can differ from person to person

In select situations, preoperative GLP-1-RA discontinuation may be considered, with the caveat that it may result in perioperative hyperglycemia