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Similarly, the highly anticipated EVOKE and EVOKE+ phase 3 trials of oral semaglutide in early Alzheimers disease reported in November 2025 that semaglutide failed to meet its primary endpoints : while it reduced several AD-related biomarkers by up to 10%, these changes did not translate into cognitive or functional benefit ( [72] )

Conclusion The study found that GLP-1RA therapy is effective not only in managing blood glucose levels in individuals with type 2 diabetes but also in reducing body weight in obese individuals and changing unhealthy eating tendencies, such as the tendency to eat in response to external food cues (external eating)

Perhaps what did the most to turn the public against steroids was the sense that some athletes were breaking the rules and getting away with it

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Available from: (cited 2025 May 7)