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Among the key regulatory protein which may be targeted by the dehydro-alanine glutathione analog are Keap1 Nrf2, the sensing cysteine thiolate of which can be chemically modified by electrophiles (such as the lipid-derived HNE) and triggers the transcription of genes for antioxidant proteins and for the intermediate metabolism [143]

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J Med Chem (2015) 58:737080

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