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Research published in obesity medicine journals demonstrates that gradual titration produces greater fat loss and better metabolic adaptation than rapid dose escalation

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Hence, while oral semaglutide and SGLT2 inhibitors offer comparable benefits for glycemic control and weight reduction, clinicians must consider the potential for skeletal muscle loss when prescribing SGLT2 inhibitors, particularly in those vulnerable to sarcopenia or frailty

Epub 2008 Jan 9..10.1038/sj.ki.5002769 [PubMed: 18185506] [CrossRef] 242

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