Most reported symptoms lack robust causal evidence and may reflect coincidental findings or underlying conditions
Other agents are vitamin K, probenecid, naphthalene, nalidixic acid, dimercaprol, and phenylhydrazine
10.1074/jbc.RA120.013607 31 KimH
To charge RHEB with GTPS (Abcam) or GDP (Sigma-Aldrich), RHEB was first diluted in buffer (50 mM HEPES, pH 7.5, 150 mM NaCl, 1 mM TCEP, 5 mM EDTA) and then supplemented with GDP or GTPS at a 30-fold molar excess
In our model the computed value of GSH transport out of the cell (Table 4) is V cGSHb = 1152 and the rates of Cys, Gly, and Glut import are also high (Table 4), although we assume that 10% per hour of the amino acids in the blood are lost to non-liver cells and an additional 25% of Cys is lost by conversion to cystine