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PDI was found to be consistently modified by 4-HNE, specifically at the cysteine residue in its active site

Several studies have reported rather high intracellular concentration of reduced glutathione, in liver cells it reaches 10 mM (Ballaroti et al

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Tests such as the Trio-Smart 3-Gas Breath Test can help identify whether SIBO, IMO, or ISO is present, supporting more informed clinical decisions

Current single-nucleus RNA-seq datasets from human AD tissue reveal distinct ferroptosis-related transcriptional programs in glial cells, including upregulation of TFRC, FTH1, SLC40A1, and ACSL4, which indicate enhanced iron turnover and lipid peroxidation susceptibility (Leng et al., 2021)