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The accumulation of -Syn in excess also activates the autophagy-lysosomal pathway (Zhang et al., 2018), mutations in -Syn proteins undergo misfolding in transcription-translation to produce toxicity, and defective mitophagy further exacerbates neurotoxicity, leading to neuronal loss or damage (Wang et al., 2018)

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J Assist Reprod Genet 22(910):361368 Parkhitko AA, Jouandin P, Mohr SE, Perrimon N (2019) Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species