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Mol Cancer Ther 5(2):418429 Reed JA, Loganzo F Jr, Shea CR, Walker GJ, Flores JF, Glendening JM, Bogdany JK, Shiel MJ, Haluska FG, Fountain JW et al (1995) Loss of expression of the p16/cyclin-dependent kinase inhibitor 2 tumor suppressor gene in melanocytic lesions correlates with invasive stage of tumor progression

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Preclinical toxicity evaluations indicate that intravenous administration of AsVI at 1.0 mg/kg in rats induces maternal toxicity, while doses exceeding 0.5 mg/kg exhibit fetotoxic effects without teratogenicity (Jiangbo et al., 2009)

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