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Isingrini E, Camus V, Le Guisquet A-M, Pingaud M, Devers S, Belzung C (2010) Association between repeated unpredictable chronic mild stress (UCMS) procedures with a high fat diet: a model of fluoxetine resistance in mice

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doi: 10.3390/nu12051325

A residue substitution of Lys 34 to Arg 34 occurs to avoid the fatty acid being installed in a wrong place.3 Liraglutide has an intravenous half-life of 810 h and 1315 h half-life after subcutaneous administration.2 Semaglutide converges these principles: the second residue is replaced by -aminoisobutyric acid (Aib) to avoid DPP-4 degradation, Lys 34 is replaced by Arg 34 , and a C18 fatty acid is linked to Lys 26 via a Glu-2xOEG spacer (Figure 1) providing higher affinity to albumin.2 The half-life of semaglutide after subcutaneous administration is up to 183 h.4 GIP plays an important role in the incretin effect in healthy people