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For example, when Wendel and coworkers sought to evaluate LPO as a mechanism of APAP-induced cell death, they intended to enhance susceptibility by feeding the animals a vitamin E-deficient diet high in PUFAs

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Oxidized glutathione (GSSG) has already donated its electrons and must be converted back to GSH by glutathione reductase before it can function as an antioxidant again

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