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Both achieve similar weight loss when doses are matched appropriately, but injection typically requires lower doses due to better absorption

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however, because data showed that semaglutide was so clearly effective in improving heart failure and mortality outcomes in a high-risk population of people with type 2 diabetes and CKD, Ozempic was well-positioned to become a treatment option for heart failure, too

Abstract To determine whether combination therapy (semaglutide + metformin) is more efficacious than monotherapy (metformin alone) in reducing the risk of antipsychotic-induced weight gain (AIWG) in patients with Type 2 Diabetes Mellitus (T2DM)