Glutamate, cysteine, and glycine serve as precursors for GSH and NADPH, key molecules that neutralize reactive oxygen species (ROS) and maintain cellular redox balance [9, 57]
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A defect in homocysteine methyltransferase or a deficiency of B 12 may lead to a so-called "methyl-trap" of THF, in which THF converts to methyl-THF, causing a deficiency in folate