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In preclinical research models, it has been studied extensively for its involvement in angiogenesis (new blood vessel formation), fibroblast activity and collagen synthesis, growth factor modulation (including VEGF and EGF pathways), connective tissue signaling in muscle, tendon, and ligament models, gastrointestinal mucosal integrity, and inflammatory cytokine modulation

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Harder training stresses tendons and ligaments beyond their current capacity, and testosterone itself appears to shift collagen turnover in ways that can outpace repair

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