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MET forms clusters at excitatory synapses in relatively mature cultured hippocampal neurons and co-localizes with the post-synaptic protein PSD-95 and with the glutamatergic N-methyl-D-aspartate (NMDA) receptor subunit GluN2B (Tyndall and Walikonis, 2006)

Addictive substances rewire this pathway to cause the body to crave more of the substance so the behavior is repeated

Jansen J, Jansen K, Neven E et al (2019) Remote sensing and signaling in kidney proximal tubules stimulates gut microbiome-derived organic anion secretion

The effect of developmental iron deficiency on gene expression, tet proteins, and Dna hydroxymethylation in the rodent brain

Self-Monitoring: Advises regular home glucose checks to detect potential hypoglycemia, especially during dose escalation