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Metabolic adaptation is most likely the reason for this plateau [11] rather than poor response or resistance to the medication

Oxidative stress markers increased significantly in line with the disease severity while antioxidant marker levels decreased ( Table 4 )

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*Correspondence: Jianmin Liang, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers