Before human translation, essential parameters to define: optimal dosing, infusion/administration route, frequency, biomarkers to monitor (senescent cell burden, inflammatory cytokines, organ function), long-term follow-up for adverse outcomes (especially tumour risk)
Other amino acids, such as Lysine and Branched-Chain Amino Acids (BCAAs) with leucine, isoleucine, and valine, may also be of interest for the synthesis of active molecules
Thus, we selected the GSH metabolism pathway to do further study
Bruheim K, Guren MG, Skovlund E, Hjermstad MJ, Dahl O, Frykholm G et al (2010) Late side effects and quality of life after radiotherapy for rectal cancer
If your situation fits, we order labs and design a protocol