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Studies that examined the efficacy of GLP-1 RA with respect to cardiovascular outcomes noted a remarkable reduction in MACE in both sexes [67,68], although without apparent sex-related divergence (hazard ratio of MACE occurrence 0.88 in both sexes) [68]

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Experimental data suggest it may accelerate gastric emptying and support contractility of gastric smooth muscle under certain conditions

Unable to relax, the appendix wall severely limits its intraluminal volume, so mucus accumulation leads to inflammation of the appendix, known generically as appendicitis

Convenience: Supplements are easier for daily self-management