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447 Moreover, these agents promote hemodynamic equilibrium, 18 diminish thrombotic propensity, 448 alleviate endothelial oxidative stress, 449 attenuate inflammatory processes, 450 and foster a favorable balance of the gut microbiota, 451 all of which collectively contribute to the salutary effects of these agents in patients with AS

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2024, doi: 10.2147/JIR.S442106

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Importantly, there is evidence that the effects of both medications varies by disease stage [47, 48], although results from real-world studies of SGLT2is support their effectiveness on cardiovascular and kidney outcomes in broader populations [49, 50]