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This observation ultimately led to the approval of higher-dose formulations of liraglutide (Saxenda) and semaglutide (Wegovy) specifically for sustained weight management, formally repositioning GLP-1 medications as obesity treatments rather than solely diabetes medications
When first studied, researchers primarily wanted to ensure they were safe for the heart
The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes
NAPRA National Association of Pharmacy Regulatory Authorities: Compounding Standards: Canadian standards for pharmacy compounding
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