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Additionally, Cucurbitacin B (CuB) stimulates GLP-1 secretion via the bitter taste receptor TAS2R10 and, similar to Metformin, induces hypoglycemic effects in diabetic mice [194]

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While these factors have been implicated in the development of GD, it is important to note that the underlying mechanisms of the disease are complex and multifactorial

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In some patients, symptoms may lessen or resolve after metoclopramide is stopped

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