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Nausea, vomiting, and diarrhea can reduce caloric intake and dehydrate patients, which may paradoxically increase blood clotting risk if fluids are not replenished

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Irregular Pigmentation Some patients experience changes in skin coloration

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The FDA classification of retatrutide has raised regulatory discussion as the compound has 39 alpha amino acids in its main chain, just below the 40 amino acid threshold used to distinguish between peptides and proteins