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Polyunsaturated fatty acids and their metabolites play physiological roles: energy provision, membrane structure, fluidity, flexibility and selective permeability of cellular membranes, and cell signaling and regulation of gene expression (Catala, 2006)

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Adipocyte-specific deficiency of NADPH oxidase 4 delays the onset of insulin resistance and attenuates adipose tissue inflammation in obesity

23 These factors, along with dynamic interactions within the TME, play crucial roles in influencing tumor proliferation and the effectiveness of antitumor immune responses

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